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Quattroflow™ Pumps Feature Operational Advantages Required for Critical Chromatography Applications

by PSG | Apr 24, 2017, Germany – April 24, 2017 – Quattroflow, part of PSG®, a Dover company and a leading brand of positive displacement quaternary diaphragm pumps, is pleased to announce that its quaternary (four-piston) diaphragm pumps provide a variety of design and operational advantages ideal for chromatography applications.

Chromatography is the method of choice for processing cell-free and protein-containing supernatants in order to isolate the “target protein” in its highest possible form. It involves passing liquid through a container (axial or radial columns) filled with a matrix that ensures the different contents are properly separated. The quality of this separation depends on maintaining a uniform flow of the liquid through the chromatographic column. The more precisely the pump transfers the different liquids through the column, the better the results. Therefore, chromatography system builders demand a pumping technology that features a smooth, reliable and flexible operation.

Realizing the importance for pumping equipment that feature the design and performance characteristics required for chromatography systems, Quattroflow offers its positive displacement quaternary pumps. Quattroflow quaternary pumps utilize no moving parts to provide non-slip operation, which is optimal for transferring shear-sensitive products without damage while virtually eliminating particle generation and heat degradation. In addition, Quattroflow pumps are self-priming and provide safe dry-run operation and allow for clean-in-place (CIP), sterilize-in-place (SIP) and autoclave capabilities. Other features that make Quattroflow pumps ideal for use in chromatography applications includes a flexible, simple control (no stroke adjustment) and easy maintenance. Also, Quattroflow pump chambers are available in stainless steel and in plastic as a single-use option.

When speaking specifically about chromatography systems, Quattroflow pumps are an ideal solution for “column packs” applications. For these applications, the use of a Quattroflow pump can result in a significant increase in the average number of trays (HETP), which in turn is a measure of the separation performance. Quattroflow pumps also have extremely low pulsation, which ensures the packing density is more uniform. In addition, the unusually large flow area of a Quattroflow pump allows the evaluation of the chromatographic column after the introduction of the matrix, the “packing” of the column with the same pump.

For more information on Quattroflow, please go to Quattroflow is a product brand within PSG, a Dover company. For more information on PSG, please go to

About Quattroflow: 
Quattroflow is a leading brand of quaternary (four-piston) diaphragm pumps that primarily serve industries such as pharmaceutical and biopharmaceutical that require gentle displacement, reliability, product safety, purity and cleanability. Headquartered in Duisburg, Germany, Quattroflow is part of PSG® , a Dover company. For more information on Quattroflow and its complete family of four-piston pumps, please visit For more information on PSG and any of its leading brands, please visit

About Dover Corporation:

Dover is a diversified global manufacturer with annual revenue of approximately $7 billion. We deliver innovative equipment and components, specialty systems, consumable supplies, software and digital solutions, and support services through three operating segments: Engineered Systems, Fluids and Refrigeration & Food Equipment. Dover combines global scale with operational agility to lead the markets we serve. Recognized for our entrepreneurial approach for over 60 years, our team of approximately 24,000 employees takes an ownership mindset, collaborating with customers to redefine what's possible. Dover is headquartered in Downers Grove, IL, USA.

Marketing Contact:
Rainer Frericks, Director of Marketing 
PSG®, a Dover company.
+49 2065 89205-0 513-280-0047 or

Media Contact:
Darren Wight, VP Media & Publicity
DeanHouston (agency for PSG®)
513-280-0047 or